Publications

 

Chen D, Drombosky KW, Hou Z, Sari L, Kashmer OM, Ryder BD, Perez VA, Woodard DR, Lin MM, Diamond MI, Joachimiak LA. Tau local structure shields an amyloid-forming motif and controls aggregation propensity. Nat Comm. 2019 June 7.

Gestaut D, Limatola A, Joachimiak LA, Frydman J. The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story. Curr Opin Struct Biol. in press.

Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J. The chaperonin TRiC/CCT associates with Prefoldin through a conserved electrostatic interface essential for cellular proteostasis. Cell. 2019 Mar 22 (PMID 30955883).

Mirbaha H, Chen D, Morazova O, Ruff KM, Sharma AM, Liu X, Goodarzi M, Pappu RV, Colby DW, Mirzaei H, Joachimiak LA, Diamond MI. Seed-competent tau monomers suggest structural origins of aggregation. elife. 2018 July 10.

Baias M, Smith PES, Shen K, Joachimiak LA, Zerko S, Kozminski W, Frydman J, Frydman L. Structure and Dynamics of the Huntington exon-1 N-terminus: A solution NMR perspective. J Am Chem Soc 2017 Jan 13

Walzthoeni T, Joachimiak LA, Rosenberger G, Röst H, Malmström L, Leitner A, Frydman J and Aebersold R. xTract: a software to quantify chemical cross-links by mass spectrometry. Nat Methods 2015 Oct 26

Joachimiak LA, Walzthoeni T, Liu C, Aebersold R, Frydman J. The structural basis for substrate recognition by the eukaryotic chaperonin TRiC/CCT. Cell 2014 Nov 20

Leitner A, Joachimiak LA, Unverdorben P, Walzthoeni T, Förster F, Aebersold R. Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes. Proc Natl Acad Sci USA 2014 Jul 1

Sontag EM, Joachimiak LA, Tan X, Tomlinson A, Hausman DE, Glabe CG, Potkin SG, Frydman J, Thompson LM. Exogenous deliver of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes. Proc Natl Acad Sci USA 2013 Jan 30

Reissmann S, Joachimiak LA, Chen B, Meyer A, Nguyen A, Frydman J. A gradient of ATP affinities generates an asymmetric power stroke driving the cycle of chaperonin TRiC/CCT. Cell Reports. 2012 Oct 3; S2211-1247(12)

Leitner A, Joachimiak LA, Bracher A, Mönkemeyer L, Walzthoeni T, Chen B, Pechmann S, Holmes S, Cong Y, Ma B, Ludtke S, Chiu W, Hartl FU, Aebersold R, Frydman J. The molecular architecture of the eukaryotic chaperonin TRiC/CCT. Structure. 2012 May 9; 20(5):814-25.

Zhang J, Ma B, DiMaio F, Douglas NR, Joachimiak LA, Baker D, Frydman J, Levitt M and Chiu W. Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure. Structure. 2011 May 11;19(5):633-9.

Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Chung S, Albeck S, Unger T, Hu W, Liu G, Delbecq S, Montelione G, Speigel C, Liu D and Baker D. A de novo binding pair by computational design and in vitro evolution. Mol Cell. 2011 Apr 22;42(2):250-60.

Tam S, Spiess C, Auyeung W, Joachimiak LA, Chen B, Poirier MA and Frydman J. The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation. Nat Struct Mol Biol. 2009 Nov 15 Rated “Recommended” Faculty of 1000

Keeble AH, Joachimiak LA, Mate MJ, Meenan N, Kirkpatrick N, Baker D and Kleanthous C. Experimental and computational analysis of the energetic basis for dual recognition of immunity proteins by colicin endonucleases. Journal of Molecular Biology. 2008 Jun 13;379(4):745-59.

Joachimiak LA, Kortemme T, Stoddard BS and Baker D. Computational design of a new hydrogen bond network and a greater than 300-fold specificity switch at a protein-protein interface. Journal of Molecular Biology. 2006 Aug 4;361(1):195-208.

Nair BM, Joachimiak LA, Chattopadhyay S, Montano I and Burns JL. Conservation of a novel protein associated with an antibiotic efflux operon in Burkholderia cenocepacia. FEMS Microbiology Letters. 2005 Apr 15;245(2):337-44.

Kortemme T, Joachimiak LA, Bullock AN, Schuler AD, Stoddard BL and Baker D. Computational redesign of protein-protein interaction specificity. Nat Struct Mol Biol. 2004 Apr;11(4):371-9.

Complete List of Published Work in MyBibliography:  

http://www.ncbi.nlm.nih.gov/sites/myncbi/1X3fpNU1UYKk2/bibliography/50404207/public/?sort=date&direction=ascending