Joachimiak graphical_abstract

We seek to understand the underlying principles of molecular recognition and specificity for macromolecular complexes involved in misfolding diseases. To achieve this we develop strategies that integrate mass spectrometry with structural and computational approaches to understand the structure function relationship of protein machinery involved in protein misfolding pathways. How protein-based molecular recognition drives protein misfolding diseases is an important fundamental question in understanding the mechanisms underlying neurodegenerative diseases.